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1

Stereochemistry of 1,2-elimination reactions at the E2–E1cB interface—tert-butyl 3-tosyloxybutanoate and its thioester

Mohrig, Jerry R., Alberg, David G., Cartwright, Craig H., Pflum, Mary Kay H., Aldrich, Jeffrey S., Anderson, J. Kyle, Anderson, Shelby R., Fimmen, Ryan L., Snover, Amy K.

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 142 KB

english, 2008

2

Phosphorylation-Dependent Kinase–Substrate Cross-Linking

Sujit Suwal, Mary Kay H. Pflum

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 397 KB

english, 2010

3

Phosphorylation-Dependent Kinase–Substrate Cross-Linking

Sujit Suwal, Mary Kay H. Pflum

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 397 KB

english, 2010

4

Exploring Kinase Cosubstrate Promiscuity: Monitoring Kinase Activity through Dansylation

Keith D. Green, Mary Kay H. Pflum

Journal:

Year:

2009

Language:

english

File:

PDF, 205 KB

english, 2009

5

Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid

Anton V. Bieliauskas, Sujith V.W. Weerasinghe, Mary Kay H. Pflum

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

6

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold

Erinprit K. Singh, Suchitra Ravula, Chung-Mao Pan, Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Sujith V.W. Weerasinghe, Mary Kay H. Pflum, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 157 KB

english, 2008

7

Grafting Miniature DNA Binding Proteins

Mary Kay H Pflum

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 40 KB

english, 2004

8

Limited proteolysis of human histone deacetylase 1

Nayana Kamath, Paulina Karwowska-Desaulniers, Mary Kay H Pflum

Journal:

BMC Biochemistry

Year:

2006

Language:

english

File:

PDF, 1.16 MB

english, 2006

9

A histone deacetylase-dependent screen in yeast

Sujith V.W. Weerasinghe, Magdalene Wambua, Mary Kay H. Pflum

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 629 KB

english, 2010

10

H-NS gives invading DNA the silent treatment

Pflum, Mary Kay H

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 241 KB

english, 2006

11

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity

Sun Ea Choi, Sujith V.W. Weerasinghe, Mary Kay H. Pflum

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 261 KB

english, 2011

12

Histone deacetylase 1 phosphorylation at S421 and S423 is constitutive in vivo, but dispensable in vitro

Paulina Karwowska-Desaulniers, Anastasia Ketko, Nayana Kamath, Mary Kay H. Pflum

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 770 KB

english, 2007

13

Isoform-selective histone deacetylase inhibitors

Bieliauskas, Anton V., Pflum, Mary Kay H.

Journal:

Chemical Society Reviews

Year:

2008

Language:

english

File:

PDF, 1.13 MB

english, 2008

14

Biotinylated Phosphoproteins from Kinase-Catalyzed Biotinylation are Stable to Phosphatases: Implications for Phosphoproteomics

Senevirathne, Chamara, Pflum, Mary Kay H.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.00 MB

english, 2013

15

Kinase-Catalyzed Biotinylation for Phosphoprotein Detection

Green, Keith D., Pflum, Mary Kay H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 100 KB

english, 2007

16

Structural Analysis of ATP Analogues Compatible with Kinase-Catalyzed Labeling

Suwal, Sujit, Senevirathne, Chamara, Garre, Satish, Pflum, Mary Kay H.

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 2.68 MB

english, 2012

17

A comparative study of ATP analogs for phosphorylation-dependent kinase–substrate crosslinking

Garre, Satish, Senevirathne, Chamara, Pflum, Mary Kay H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.27 MB

english, 2014

18

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position

Choi, Sun Ea, Pflum, Mary Kay H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 261 KB

english, 2012

19

Residues in the 11 Å Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors †

Weerasinghe, Sujith V. W., Estiu, Guillermina, Wiest, Olaf, Pflum, Mary Kay H.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.21 MB

english, 2008

20

Phosphopeptide Modification and Enrichment by Oxidation–Reduction Condensation

Warthaka, Mangalika, Karwowska-Desaulniers, Paulina, Pflum, Mary Kay H.

Journal:

ACS Chemical Biology

Year:

2006

Language:

english

File:

PDF, 227 KB

english, 2006

21

Cyclic AMP Response Element-Binding Protein (CREB) and CAAT/Enhancer-Binding Protein β (C/EBPβ) Bind Chimeric DNA Sites with High Affinity †

Flammer, Jamie R., Popova, Katerina N., Pflum, Mary Kay H.

Journal:

Year:

2006

Language:

english

File:

PDF, 471 KB

english, 2006

22

Mutagenesis Studies of the 14 Å Internal Cavity of Histone Deacetylase 1: Insights toward the Acetate-Escape Hypothesis and Selective Inhibitor Design

Wambua, Magdalene K., Nalawansha, Dhanusha A., Negmeldin, Ahmed T., Pflum, Mary Kay H.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.70 MB

english, 2014

23

Hepatitis B Virus X Protein Activates Transcription by Bypassing CREB Phosphorylation, Not by Stabilizing bZIP−DNA Complexes †

Pflum, Mary Kay H., Schneider, Tanya L., Hall, David, Schepartz, Alanna

Journal:

Year:

2001

Language:

english

File:

PDF, 306 KB

english, 2001

24

The generality of kinase-catalyzed biotinylation

Senevirathne, Chamara, Embogama, D. Maheeka, Anthony, Thilani A., Fouda, Ahmed E., Pflum, Mary Kay H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

25

A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation

Fouda, Ahmed E., Pflum, Mary Kay H.

Journal:

Angewandte Chemie

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

26

A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation

Fouda, Ahmed E., Pflum, Mary Kay H.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

27

Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid

Bieliauskas, Anton V., Weerasinghe, Sujith V. W., Negmeldin, Ahmed T., Pflum, Mary Kay H.

Journal:

Archiv der Pharmazie

Year:

2016

Language:

english

File:

PDF, 2.46 MB

english, 2016

28

K-CLASP: A tool to identify phosphosite specific kinases and interacting proteins

Dedigama-Arachchige, Pavithra M., Pflum, Mary Kay H.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.06 MB

english, 2016

29

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue

Almaliti, Jehad, Al-Hamashi, Ayad A, Negmeldin, Ahmed T, Hanigan, Christin l, Perera, Lalith, Pflum, Mary Kay H., Casero, Robert A., Tillekeratne, L. M. Viranga

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

30

K-BILDS: A Kinase Substrate Discovery Tool

Embogama, D. Maheeka, Pflum, Mary Kay H.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.29 MB

english, 2017

31

LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation

Nalawansha, Dhanusha A., Pflum, Mary Kay H.

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.33 MB

english, 2017

32

NIH Public Access

Bieliauskas, Anton V, Pflum, Mary Kay H

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

33

Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity

Negmeldin, Ahmed T., Padige, Geetha, Bieliauskas, Anton V., Pflum, Mary Kay H.

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 2.47 MB

english, 2017

34

HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation

Nalawansha, Dhanusha A., Gomes, Inosha D., Wambua, Magdalene K., Pflum, Mary Kay H.

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 3.48 MB

english, 2017

35

The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity

Negmeldin, Ahmed T., Pflum, Mary Kay H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 855 KB

english, 2017

36

The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity

Negmeldin, Ahmed T., Knoff, Joseph R., Pflum, Mary Kay H.

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

37

Kinase-catalyzed biotinylation of DNA

Anthony, Thilani M., Pflum, Mary Kay H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 556 KB

english, 2018

38

Identification of PP1-Gadd34 substrates involved in the unfolded protein response using K-BIPS, a method for phosphatase substrate identification

Dedigama-Arachchige, Pavithra M, Acharige, Nuwan P. N., Pflum, Mary Kay

Journal:

Molecular Omics

Year:

2018

Language:

english

File:

PDF, 1.96 MB

english, 2018

39

Chitosan-assisted permeabilization of ATP–biotin for live cell kinase-catalyzed biotinylation

Fouda, Ahmed E, Embogama, D Maheeka, Ramanayake-Mudiyanselage, Vindya, H Pflum, Mary Kay

Journal:

Year:

2018

Language:

english

File:

PDF, 1.66 MB

english, 2018

40

Identification of kinases and interactors of p53 using kinase-catalyzed crosslinking and immunoprecipitation (K-CLIP)

Garre, Satish, Gamage, Aparni K, Faner, Todd R, Dedigama-Arachchige, Pavithra, Pflum, Mary Kay H.

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

41

HDAC1 Substrate Profiling using Proteomics-Based Substrate Trapping

Nalawansha, Dhanusha A, Zhang, Yuchen, Herath, Kavinda, Pflum, Mary Kay H.

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 903 KB

english, 2018

42

Optimal substrate trapping mutants to discover substrates of HDAC1

Gomes, Inosha D, Pflum, Mary Kay H.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.21 MB

english, 2019

43

In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors

Tillekeratne, L. M. Viranga, Al-Hamashi, Ayad Ayad, Dlamini, Samkeliso, Taylor, William, Koranne, Radhika, Pflum, Mary Kay, Negmeldin, Ahmed T., Knoff, Joseph

Journal:

Proceedings (American Bar Association. Section of International and Comparative Law)

Year:

2019

Language:

english

File:

PDF, 134 KB

english, 2019

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